Effect of Alpha-tocopherol on Hemato-biochemical Profiles of Broilers in Deltamethrin Induced Toxicity

Deltamethrin is a broad-spectrum insecticide mainly used to protect crops, fruit and vegetables from mites, ants, weevils, beetle etc. Thus deltamethrin contaminated food of commercial poultry diet may cause toxic effects in broilers and indirect adverse effects on human through food chain. Therefore, hematological and biochemical alterations in White Leghorn birds due to deltamethrin induced toxicity along with protective effect of alpha-tocopherol were evaluated. A dose dependent decrease in hemoglobin, packed cell volume, total erythrocyte count and increase in serum ALT and AST levels were noticed in deltamethrin exposed birds after 42 days in comparison to control. Reduction in ALT and AST levels with alpha-tocopherol were observed, however serum level of total protein, creatinine and BUN remained unaltered. Exposure of birds to deltamethrin at 100 to 150 mgkg-1 was found capable of inducing hematological and biochemical alterations which could be effectively ameliorated by alpha tocopherol at 300 mg kg.